HY-B0215-Acetylcysteine试剂-杭州昊鑫生物科技股份有限公司手机版

详细介绍

Acetylcysteine试剂生物活性

NAC(防治)是一种黏液溶解的代理,减少粘液的厚度。NAC是一种活性氧抑制剂[1]。乙酰半cystine是一种半cystine前体,防止hemin-induced ferroptosis通过中和生成有毒的脂质arachidonate-dependent 5-lipoxygenases活动[5]。NAC诱发细胞凋亡[2][3]。NAC还具有抗流感病毒活动

Acetylcysteine试剂IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons^[2].
Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells^[3].
Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group Acetylcysteine 300. Lung glutathione peroxidase is significantly increases in group Acetylcysteine 300 (P=0.04), while the other oxidation biomarkers show no significant differences^[6].
Acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

163.19

性状

Solid

Formula

C₅H₉NO₃S

CAS 号

616-91-1

中文名称

结构分类

Ketones, Aldehydes, Acids

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 163 mg/mL (998.84 mM; ultrasonic and adjust pH to 7 with NaOH)

DMSO : ≥ 100 mg/mL (612.78 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.1278 mL	30.6391 mL	61.2783 mL
5 mM	1.2256 mL	6.1278 mL	12.2557 mL
10 mM	0.6128 mL	3.0639 mL	6.1278 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 120 mg/mL (735.34 mM); Clear solution; Need ultrasonic

500 mg	400元	10000 可售
5 g	500元	10000 可售
10 g	600元	10000 可售

产品简介

详细介绍