Cardiac Troponin I/TNNC1心肌肌钙蛋白抗体齐一生物科技（上海）有限公司新品*欢迎您访问我们的如有什么问题请给我们或者留言741653262,告诉我您的需要,并留下您宝贵的意见和建议.

Cardiac Troponin I/TNNC1心肌肌钙蛋白抗体英文名称    Cardiac Troponin I/TNNC1
中文名称    心肌肌钙蛋白抗体
别    名    troponin I type 3 (cardiac); Cardiac troponin I; Troponin I, cardiac muscle; Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC-1; TNNC1; TNNI3; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; troponin I, cardiac 3; TroponinI; CTn1; Troponin I; TNNI3_HUMAN.
研究领域    心血管  免疫学  
抗体来源    Rabbit
克隆类型    Polyclonal
交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
相关标记    Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC 
产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    23kDa
性    状    Lyophilized or Liquid
浓    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human CTn1
亚    型    IgG
纯化方法    affinity purified by Protein A
储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍    background:
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin plex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory plex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit:
Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1.

Post-translational modifications:
Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).

DISEASE:
Defects in TNNI3 are the cause of familial hypertrophic cardiomyopathy type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. 
Defects in TNNI3 are the cause of familial restrictive cardiomyopathy type 1 (RCM1) [MIM:115210]. RCM1 is a heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. 
Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. 
Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Similarity:
Belongs to the troponin I family.

Gene ID:
7137

Database links:
Entrez Gene: 7137 Human
Entrez Gene: 21954 Mouse
Entrez Gene: 100049696 Pig
Entrez Gene: 29248 Rat
Omim: 191044 Human
SwissProt: P19429 Human
SwissProt: P48787 Mouse
SwissProt: P23693 Rat
Unigene: 709179 Human
Unigene: 27674 Mouse
Unigene: 64141 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

心肌肌钙蛋白（Cardiac Troponin CTn1）是心肌收缩的调节蛋白，存在于心肌收缩蛋白的细肌丝上。肌钙蛋白的作用之一是把原肌凝蛋白（Tropomyosin.Tm）附着于肌动蛋白（Action.A）上、 主要用于心肌功能方面的研究。