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多药耐药蛋白/P-糖蛋白抗体MDR1英文名称    MDR1
中文名称    多药耐药蛋白/P-糖蛋白抗体
别    名    P-Glycoprotein; Multi Drug Resistance Associated Protein, ABCB1; ATP-binding cassette sub-family B (MDR/TAP), member 1; ABC20; CD243; CD243 antigen; CLCS; Multidrug resistance protein 1; P glycoprotein 1; p-GP; gp170; P gp; PGY1; MDR1_HUMAN.
研究领域    肿瘤  心血管  细胞生物  免疫学  信号转导  转录调节因子  
抗体来源    Rabbit
克隆类型    Polyclonal
交叉反应    Human, Mouse, Rat, 
产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500  （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    141kDa
细胞定位    细胞膜 
性    状    Lyophilized or Liquid
浓    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human MDR1
亚    型    IgG
纯化方法    affinity purified by Protein A
储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed    PubMed
产品介绍    background:
malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in saras and leukemias / lymphomas.

Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Subunit:
Interacts with PSMB5.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity).

Tissue Specificity:
Expressed in liver, kidney, small intestine and brain.

DISEASE:
Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are monly classified as autoimmune diseases.

Similarity:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Database links:
Entrez Gene: 5243 Human
Entrez Gene: 18669 Mouse
Entrez Gene: 170913 Rat
Entrez Gene: 24646 Rat
Omim: 171050 Human
SwissProt: P08183 Human
SwissProt: P06795 Mouse
SwissProt: P43245 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.