C-反应蛋白抗体Anti-CRP齐一生物科技有限公司主要经营进口原装Elisa试剂盒，种类齐全，价格实惠，货期短。购买我公司ELISA产品客户，可享免费代测、全程技术指导：(包括售前标本收集、后期实验、实验结束后数据分析等技术问题，我公司会有专业的技术即时给您去电沟通、解决。)保证售后服务。

C-反应蛋白抗体Anti-CRP相关标记    Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名称    CRP
中文名称    C-反应蛋白抗体
研究领域    心血管  免疫学  信号转导  细胞凋亡  生长因子和激素  
抗体来源    Rabbit
克隆类型    Polyclonal
交叉反应    Human, Mouse, Rat, Dog, Pig, Rabbit, 
产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500（石蜡切片需做抗原修复） 
 not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    25kDa
细胞定位    分泌型蛋白 
性    状    Lyophilized or Liquid
浓    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human CRP (151-200aa)
亚    型    IgG
纯化方法    affinity purified by Protein A
储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍    background:
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P ponent (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the mon pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.

Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and plement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subunit:
Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular Location:
Secreted.

Tissue Specificity:
Found in plasma.

Similarity:
Belongs to the pentaxin family.
Contains 1 pentaxin domain.

Gene ID:
1401

Database links:
Entrez Gene: 1401 Human
Omim: 123260 Human
SwissProt: P02741 Human
Unigene: 76452 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

C反应蛋白 CRP（C-reactive protin）是与C性肺炎球菌的多糖起反应的一种蛋白，在某些细菌的感染过程中出现在血浆中。
CRP是在一些病理性情况下出现于病人血清中的一种糖蛋白，特别是在伴有肯炎症和组织坏死疾病的急性期。血清中出现的这种异常蛋白能和肺炎C-多糖体发生沉淀反应，当疾病好转或缓解时，CRP减低或消失。
临床意义:
(1)各种急性化脓性炎症、菌血症、组织坏死(心肌梗塞、手术、严重创伤、烧伤等)、恶性肿瘤、结缔组织病、肾移殖后急性排异反应、急性风湿热、风湿性关节炎、类风湿性关节炎、心肌炎急性期、肺炎、肺结核、系统性红斑狼疮、急性肝炎和阑尾炎等，血清中CRP含量可增高，它的出现比其它急性期的反应物质早，所以对疾病的早期诊断很有帮助。
CRP可以鉴别细菌炎症或者是病毒性炎症。细菌性炎症CRP可以明显增高，而病毒性炎症CRP的血清含量一般都在正常范围。
产品图片    
Antigen: bs-0155P, 0.2ug/100ul 
Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; 
Secondary: HRP conjugated Goat-Anti- Rabbit IgG(bs-0295G-HRP) at 1: 5000; 
TMB(C-0024) staining; 
Read the data in MicroplateReader by 450nm. 

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-CRP Polyclonal Antibody, Unconjugated(bs-0155R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

Tissue/cell: mouse intestine tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-CRP Polyclonal Antibody, Unconjugated(bs-0155R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining