N-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺

CAS:66701-25-5

英文名称：E-64

别名：E-64蛋白酶抑制剂;反-环氧丁二酰基-L-亮氨酰胺基(4-胍基)丁烷

保存：-20℃

分子式：C15H27N5O5

分子量：357.41

MDL：MFCD00080261

用途：E-64是一种亲和纯化半胱氨酸蛋白酶的有效配体。

是一种有效的不可逆的半胱氨酸蛋白酶 (cysteine proteases) 抑制剂，抑制 papain 的 IC50 为 9 nM。

E-64 is an epoxide which can irreversibly inhibit a wide range of cysteine peptidases.
The compound was first isolated and identified from Aspergillus japonicus in 1978. It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain.
The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause.