二苯并环辛烯PEG羧基 ，DBCO-PEG-COOH，产品芃硕生物专业供应。

（备注：非常规分子量：400、600。精确聚合度的小分子定制。）

结构式：

基本信息：

中文名称：二苯并环辛烯-聚乙二醇-羧基 (DBCO-PEG-COOH)

别名：DBCO-PEG-COOH

英文名称：DBCO-PEG-COOH，DBCO-PEG-ACID

CAS：-

分子量：400、600、1K、2K、3.4K、4K、5K、10K

纯度：95%以上

二苯并环辛烯PEG羧基 ，DBCO-PEG-COOH，产品芃硕生物专业供应。

应用简介：

Ponsure’DBCO (dibenzocyclooctyne) PEG acid, DBCO-PEG-COOH, is a heterobifunctional reactive PEG derivative that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneously without the need for toxic Cu catalysts. Carboxylic acid group, on the other hand, can be activated to react with amines, hydroxy and other functional groups.

Copper-free Click reaction procedures:

Prepare the azide-containing reagents in reaction buffer.

Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.

Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4℃.

Purify conjugates either by dialysis or size-exclusion chromatograph.

物理性质：

状态：淡黄色到白色固体，或者半固体，取决于分子量。

溶解性：溶于水，DMSO等溶剂。

保持条件：-20℃*保存，避光，干燥。

注意事项：取用一定要干燥，避免频繁的溶解和冻干。

反应性：DBCO与含有N3基团的反应。COOH可以和NH2、OH等反应。

二苯并环辛烯PEG羧基 ，DBCO-PEG-COOH，产品芃硕生物专业供应。

技术指标：

纯度（PEG）：95%以上

取代率（DBCO）：90%以上

取代率（COOH）：95%以上

分散系数（PDI）：小于等于1.05

分析：COA、GPC、NMR、MALDI-TOF

相关产品*：

MPEG-COOH

HOOC-PEG-COOH

4ARM-PEG-COOH

6ARM-PEG-COOH

8ARM-PEG-COOH

HO-PEG-COOH

BOC-NH-PEG-COOH

FMOC-NH-PEG-COOH

NH2-PEG-COOH

DSPE-PEG-COOH

DPPE-PEG-COOH

DMPE-PEG-COOH

DOPE-PEG-COOH

HOOC-PEG-T-butyl acetate

HS-PEG-COOH

OPSS-PEG-COOH

DA-PEG-COOH(ACRL-PEG-COOH)

ACA-PEG-COOH

ALKYNE-PEG-COOH

N3-PEG-COOH

MAL-PEG-COOH

LA-PEG-COOH

BIOTIN-PEG-COOH

SILANE-PEG-COOH

Cholesterol-PEG-COOH

FA-PEG-COOH

FITC-PEG-COOH

RB-PEG-COOH

CY5-PEG-COOH

DBCO-PEG-COOH

PLA-PEG-COOH

PCL-PEG-COOH

PLGA-PEG-COOH

Furan-PEG-COOH

Pyrene-PEG-COOH

二苯并环辛烯PEG羧基 ，DBCO-PEG-COOH，产品芃硕生物专业供应。