详细介绍

L-Carnitine (Synonyms: 左旋肉碱; (R)-Carnitine; Levocarnitine)

L-Carnitine 是一种高度极性的小两性离子，是线粒体β-氧化途径的重要共因子。L-Carnitine 的作用是将长链脂肪酰基辅酶- A 转运到线粒体中，通过 β-氧化降解。L-Carnitine 是一种抗氧化剂。L-Carnitine 可以改善许多先天性代谢错误的代谢失衡。

生物活性

L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism

IC₅₀ & Target

Human Endogenous Metabolite

体内研究(In Vivo)

L-Carnitine ((R)-Carnitine) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion

分子量：161.20

Formula：C₇H₁₅NO₃

CAS 号：541-15-1

中文名称：左旋肉碱

运输条件：Room temperature in continental US; may vary elsewhere.

储存方式：

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

H₂O : ≥ 50 mg/mL (310.17 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.2035 mL	31.0174 mL	62.0347 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5.

[2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675.

[3]. Uzuner N, et al. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301.

注：产品仅用于科研

产品简介

详细介绍

L-Carnitine (Synonyms: 左旋肉碱; (R)-Carnitine; Levocarnitine)