白细胞介素 33 (IL-33) 受体；信号转导需要辅助受体 IL1RAP 的关联。
它的刺激会招募 MYD88、IRAK1、IRAK4 和 TRAF6，然后磷酸化 MAPK3/ERK1 和/或 MAPK1/ERK2、MAPK14 和 MAPK8（通过相似性）。
可能参与辅助性 T 细胞功能
GS15081
Protein
Uniprot ID:P14719-2 (2-337aa)
Il1rl1, Ly84, St2, Ste2
Mammalian cell
Mus musculus (house mouse)
C-terminal FLAG-tagged；C-terminal His-tagged；
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-140℃.
For research use only
白细胞介素1受体样1 (IL1RL1)是白细胞介素1受体家族的一员，包含3个ig样c2型结构域和1个TIR结构域。它在肾、肺、胎盘、胃、骨骼肌、结肠和小肠中高度表达。IL1RL1是白细胞介素-33的受体，它的刺激招募MYD88, IRAK1, IRAK4和TRAF6，然后磷酸化MAPK3/ ERK1和/或MAPK1/ ERK2, MAPK14和MAPK8。IL1RL1可能参与辅助t细胞的功能。可溶性IL1RL1还作为Th2细胞因子产生的负调节因子，它直接涉及心脏病的进展。
