通过其SH2结构域与活化（磷酸化）蛋白-Tyr激酶结合，并充当接头，介导p110催化单元与质膜的结合。胰岛素刺激的胰岛素敏感性组织中葡萄糖摄取和糖原合成的增加所必需的。在响应 FGFR1、FGFR2、FGFR3、FGFR4、KITLG/SCF、KIT、PDGFRA 和 PDGFRB 的信号传递中发挥重要作用。同样，在ITGB2信号传导中发挥作用
GS15075
Protein
Uniprot ID:P27986(1-724aa)
PIK3R1, GRB1
Mammalian cell
Homo sapiens (Human)
C-terminal His-tagged
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-129℃.
For research use only
磷脂酰肌醇3-激酶在3 '位置磷酸化磷脂酰肌醇的肌醇环。该酶包括一个110 kD的催化亚基和一个85、55或50 kD的调节亚基。该基因编码85 kD调控亚基。磷脂酰肌醇3-激酶在胰岛素代谢过程中起着重要作用，该基因的突变与胰岛素抵抗有关。该基因的选择性剪接产生了编码不同亚型的四种转录变异。
